Early-Onset AD: Clinical and Genetic Analyses

 
   Lead Investigator:    Diane Jacobs
   Institution      :    U California, San Diego
   E-Mail           :    djacobs@ucsd.edu
   Proposal ID      :    803


   Publications:


1  Qiu Y, Jacobs D, Messer K, Salmon D, Feldman H
   Identifying Cognitive Subtypes of Mild-to-Moderate Alzheimer's Disease Using the National Alzheimer's Coordinating Center Uniform Dataset Neuropsychological Test Battery
   2018   Abstract  American Academy of Neurology , 

   ACCEPTED





   Proposal Description:
   This project will elucidate the clinical characteristics, disease course,         genetic contributions, and neuropathological findings of early-onset AD (EOAD).   Specific aims are to (1) Identify cognitive subtypes of EOAD using latent         class analysis of neuropsychological measures (2) Examine the predictive value    of cognitive subtype on disease course (3) Examine the diagnostic and             predictive value of behavioral symptoms in EOAD (4) Examine the contribution      of APOE-e4 genotype to clinical presentation, disease course, and pathology in    EOAD participants with no known fAD mutation and (5) For those cases who have     had autopsy, examine clinical-pathological correlations.